Boron Trifluoride-catalyzed D-Homo Rearrangements of 20β-Acetoxy-5α-pregnanes
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چکیده
منابع مشابه
Pechmann reaction promoted by boron trifluoride dihydrate.
The Pechmann reaction of substituted phenols 1a-e with methyl acetoacetate (2) can be activated by boron trifluoride dihydrate (3) to give the corresponding 4-methyl- coumarin derivatives 4a-e in excellent yield (98-99 %).
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Benign prostatic hyperplasia (BPH) is a non-malignant enlargement of the prostate gland. Itis a leading disorder of the elderly male population. Excessive production of dihydrotestosteronehas been implicated in this pathological condition. Steroidal 5α-reductase is a membrane boundNADPH dependent enzyme which is responsible for the conversion of testosterone (T) todihydrotestosterone (DHT). The...
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benign prostatic hyperplasia (bph) is a non-malignant enlargement of the prostate gland. itis a leading disorder of the elderly male population. excessive production of dihydrotestosteronehas been implicated in this pathological condition. steroidal 5α-reductase is a membrane boundnadph dependent enzyme which is responsible for the conversion of testosterone (t) todihydrotestosterone (dht). the...
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A complete series of eight 1,6:2,3- and 1,6:3,4-dianhydro-β-D-hexopyranoses were subjected to fluorination with DAST. The 1,6:3,4-dianhydropyranoses yielded solely products of skeletal rearrangement resulting from migration of the tetrahydropyran oxygen (educts of D-altro and D-talo configuration) or of the 1,6-anhydro bridge oxygen (D-allo, D-galacto). The major products yielded by the 1,6:2,3...
متن کاملGold(I)-catalyzed oxidative rearrangements.
Intermediates possessing carbenoid character have recently been postulated in a number of gold-catalyzed rearrangements.1 In accord with this proposal, cyclopropane adducts are formed from the intermolecular reaction of the proposed gold(I)-carbenoid intermediates with olefins.2 To further examine the nature of these intermediates, we sought to explore their reactivity with reagents previously ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1971
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.19.1329